Endometrial dating noyes
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The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. The endometrium becomes receptive as a result of a series of timed hormonal events during the menstrual cycle.
Embryo implantation represents the most critical step of the reproductive process in many species.
It consists of a unique biological phenomenon, by which the blastocyst becomes intimately connected to the maternal endometrial surface to form the placenta that will provide an interface between the growing fetus and the maternal circulation (Denker, 1993; Aplin, 2000).
In addition, development of functional systems to study embryo–uterine interactions will lead to better definition of the interactions existing between the molecules involved in this process.
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Attention to qualitative changes in 8 morphological factors is most useful in dating the endometrial biopsy.
During the 1st week of luteal activity, attention should be focused on changes occurring in gland epithelium: gland mitosis, pseudostratification of nuclei, basal vacuolation, and secretion.
The clinical value of the endometrial histological dating in RIF patients in natural cycle is still to be answered.
In this study, we tried to investigate the clinical effects of p FET in unexplained RIF patients according to the use of classic histologic endometrial dating to estimate the timing of the window of implantation and to adjust embryo transfer time in natural cycle.