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This sedating activity is sometimes used in managing conditions such as eczema where sleep maybe disturbed due to pruritus.
Sedating antihistamines also have significant antimuscarinic activity and should be used with caution in patients with prostatic hypertrophy, urinary retention and angle-closure glaucoma.
In order to stop taking the drug, you may need to have your dose reduced over time (tapered) with the help of a healthcare provider.Histamine-1 receptors are located in the airways, blood vessels and gastrointestinal tract (stomach and esophagus).Stimulation of these receptors can lead to conditions such as a skin rash or inflammation, a narrowing of the airways (bronchoconstriction), hay fever, or motion sickness.Sedation methods in dentistry include inhalation sedation (using nitrous oxide), oral sedation, and intravenous (IV) sedation.Inhalation sedation is also sometimes referred to as relative analgesia.
Examples of drugs which can be used for sedation include isoflurane, propofol, etomidate, ketamine, fentanyl, lorazepam and midazolam.