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He made his directorial debut a year later with the biographical spy comedy Confessions of a Dangerous Mind, and has since directed the historical drama Good Night, and Good Luck (2005), the sports comedy Leatherheads (2008), the political drama The Ides of March (2011), and the war film The Monuments Men (2014).
Clooney won an Academy Award for Best Supporting Actor for the Middle East thriller Syriana (2005), and subsequently earned Best Actor nominations for the legal thriller Michael Clayton (2007) and the comedy-dramas Up in the Air (2009) and The Descendants (2011).
After leaving ER, Clooney starred in the commercially successful films The Perfect Storm (2000), a disaster drama; and O Brother, Where Art Thou? In 2001, he teamed up with Soderbergh again for the heist comedy Ocean's Eleven, a remake of the 1960s Rat Pack film of the same name, with Clooney playing Danny Ocean, originally portrayed by Frank Sinatra.
Doug Ross on the medical drama ER, from 1994 to 1999, for which he received two Primetime Emmy Award nominations.
While working on ER, he began attracting a variety of leading roles in films, with his breakthrough role in From Dusk till Dawn (1996), and the crime comedy Out of Sight (1998), in which he first worked with director Steven Soderbergh, who would become a long-time collaborator.
His first major Hollywood role was in the horror comedy-crime thriller From Dusk till Dawn, directed by Robert Rodriguez and co-starring Harvey Keitel.
He followed its success with the romantic comedy One Fine Day with Michelle Pfeiffer, and the action-thriller The Peacemaker with Nicole Kidman.
In 2013, he received the Academy Award for Best Picture for producing the political thriller Argo.